Drug interactions
Duloxetine + Sumatriptan intranasal
Severity: Moderate
Duloxetine and Sumatriptan intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sumatriptan is a 5-HT1B/1D agonist and duloxetine increases serotonin. Serotonin syndrome has been reported with triptans and serotonin reuptake inhibitors, though the risk is low.
What this interaction means in plain words
Duloxetine and Sumatriptan intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive serotonergic effects.
What to do
The combination can be used when clearly indicated. Counsel on serotonin syndrome symptoms and monitor, particularly after dose changes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Duloxetine
- Duloxetine + Isocarboxazid Contraindicated
- Duloxetine + Linezolid Contraindicated
- Duloxetine + Methylene blue Contraindicated
- Duloxetine + Phenelzine Contraindicated
- Duloxetine + Procarbazine Contraindicated
- Duloxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Duloxetine with Sumatriptan intranasal?
MediHelp rates the interaction as moderate. Duloxetine and Sumatriptan intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sumatriptan is a 5-HT1B/1D agonist and duloxetine increases serotonin. Serotonin syndrome has been reported with triptans and serotonin reuptake inhibitors, though the risk is low.
How serious is the interaction between Duloxetine and Sumatriptan intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: The combination can be used when clearly indicated. Counsel on serotonin syndrome symptoms and monitor, particularly after dose changes.
What other medicines interact with Duloxetine?
MediHelp also lists interactions of Duloxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Duloxetine page.
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