Drug interactions
Duloxetine + Trifluoperazine
Severity: Moderate
Duloxetine and Trifluoperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Duloxetine inhibits CYP2D6, which may raise trifluoperazine exposure. This can increase sedation, extrapyramidal symptoms and hypotension.
What this interaction means in plain words
Duloxetine and Trifluoperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Duloxetine inhibits CYP2D6, reducing trifluoperazine clearance; trifluoperazine is metabolized mainly by CYP1A2, so the effect is likely modest.
What to do
Monitor for extrapyramidal symptoms, sedation and hypotension, and reduce the trifluoperazine dose if they occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Duloxetine
- Duloxetine + Isocarboxazid Contraindicated
- Duloxetine + Linezolid Contraindicated
- Duloxetine + Methylene blue Contraindicated
- Duloxetine + Phenelzine Contraindicated
- Duloxetine + Procarbazine Contraindicated
- Duloxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Duloxetine with Trifluoperazine?
MediHelp rates the interaction as moderate. Duloxetine and Trifluoperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Duloxetine inhibits CYP2D6, which may raise trifluoperazine exposure. This can increase sedation, extrapyramidal symptoms and hypotension.
How serious is the interaction between Duloxetine and Trifluoperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for extrapyramidal symptoms, sedation and hypotension, and reduce the trifluoperazine dose if they occur.
What other medicines interact with Duloxetine?
MediHelp also lists interactions of Duloxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Duloxetine page.
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