Drug interactions
Duloxetine + Valerian
Severity: Minor
Duloxetine and Valerian: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valerian has sedative properties and may add to the drowsiness and dizziness seen with duloxetine. The combination may impair alertness and psychomotor performance. Clinical data are limited.
What this interaction means in plain words
Duloxetine and Valerian have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive CNS depression, with valerian enhancing GABAergic activity.
What to do
Counsel patients about additive drowsiness and caution when driving or operating machinery. Reduce or stop valerian if excessive sedation occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Duloxetine
- Duloxetine + Isocarboxazid Contraindicated
- Duloxetine + Linezolid Contraindicated
- Duloxetine + Methylene blue Contraindicated
- Duloxetine + Phenelzine Contraindicated
- Duloxetine + Procarbazine Contraindicated
- Duloxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Duloxetine with Valerian?
MediHelp rates the interaction as minor. Duloxetine and Valerian have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Valerian has sedative properties and may add to the drowsiness and dizziness seen with duloxetine. The combination may impair alertness and psychomotor performance. Clinical data are limited.
How serious is the interaction between Duloxetine and Valerian?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients about additive drowsiness and caution when driving or operating machinery. Reduce or stop valerian if excessive sedation occurs.
What other medicines interact with Duloxetine?
MediHelp also lists interactions of Duloxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Duloxetine page.
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