Drug interactions
Duloxetine + Vorapaxar
Severity: Moderate
Duloxetine and Vorapaxar: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Duloxetine impairs platelet function and vorapaxar is a potent antiplatelet agent, so the combination may raise the risk of bleeding, including serious gastrointestinal or intracranial hemorrhage. Vorapaxar already carries a significant bleeding risk.
What this interaction means in plain words
Duloxetine and Vorapaxar can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antiplatelet effects: PAR-1 antagonism by vorapaxar plus reduced platelet serotonin uptake by duloxetine.
What to do
Monitor for bleeding signs and hemoglobin, and reassess the need for both drugs, especially in older patients or those on other antithrombotics.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Duloxetine
- Duloxetine + Isocarboxazid Contraindicated
- Duloxetine + Linezolid Contraindicated
- Duloxetine + Methylene blue Contraindicated
- Duloxetine + Phenelzine Contraindicated
- Duloxetine + Procarbazine Contraindicated
- Duloxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Duloxetine with Vorapaxar?
MediHelp rates the interaction as moderate. Duloxetine and Vorapaxar can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Duloxetine impairs platelet function and vorapaxar is a potent antiplatelet agent, so the combination may raise the risk of bleeding, including serious gastrointestinal or intracranial hemorrhage. Vorapaxar already carries a significant bleeding risk.
How serious is the interaction between Duloxetine and Vorapaxar?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding signs and hemoglobin, and reassess the need for both drugs, especially in older patients or those on other antithrombotics.
What other medicines interact with Duloxetine?
MediHelp also lists interactions of Duloxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Duloxetine page.
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