Drug interactions
Dupilumab + Typhoid vaccine live
Severity: Moderate
Dupilumab and Typhoid vaccine live: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral live typhoid vaccine (Ty21a) contains live attenuated bacteria, and its safety in dupilumab-treated patients has not been established. Altered immune signaling could in theory reduce vaccine response or permit unwanted replication.
What this interaction means in plain words
Dupilumab and Typhoid vaccine live can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Dupilumab blocks IL-4/IL-13 signaling, which may alter immune handling of live attenuated organisms; the effect is theoretical.
What to do
Use the inactivated injectable Vi polysaccharide typhoid vaccine instead during dupilumab therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dupilumab
Frequently asked questions
Can I take Dupilumab with Typhoid vaccine live?
MediHelp rates the interaction as moderate. Dupilumab and Typhoid vaccine live can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral live typhoid vaccine (Ty21a) contains live attenuated bacteria, and its safety in dupilumab-treated patients has not been established. Altered immune signaling could in theory reduce vaccine response or permit unwanted replication.
How serious is the interaction between Dupilumab and Typhoid vaccine live?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the inactivated injectable Vi polysaccharide typhoid vaccine instead during dupilumab therapy.
What other medicines interact with Dupilumab?
MediHelp also lists interactions of Dupilumab with, for example, Smallpox vaccine live, Adenovirus types 4 and 7 live, Bcg vaccine live. The full list is on the Dupilumab page.
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