Drug interactions
Dupilumab + Yellow fever vaccine
Severity: Moderate
Dupilumab and Yellow fever vaccine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Yellow fever vaccine is a live attenuated virus vaccine, and its use in patients on dupilumab has not been studied. Altered immune signaling could in theory increase the risk of vaccine-related illness or reduce protection.
What this interaction means in plain words
Dupilumab and Yellow fever vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Dupilumab blocks IL-4/IL-13 signaling, which may alter response to live attenuated viruses; the effect is theoretical.
What to do
Vaccinate before starting dupilumab when feasible; if travel to an endemic area is unavoidable, seek specialist advice or consider a medical exemption.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dupilumab
Frequently asked questions
Can I take Dupilumab with Yellow fever vaccine?
MediHelp rates the interaction as moderate. Dupilumab and Yellow fever vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Yellow fever vaccine is a live attenuated virus vaccine, and its use in patients on dupilumab has not been studied. Altered immune signaling could in theory increase the risk of vaccine-related illness or reduce protection.
How serious is the interaction between Dupilumab and Yellow fever vaccine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate before starting dupilumab when feasible; if travel to an endemic area is unavoidable, seek specialist advice or consider a medical exemption.
What other medicines interact with Dupilumab?
MediHelp also lists interactions of Dupilumab with, for example, Smallpox vaccine live, Adenovirus types 4 and 7 live, Bcg vaccine live. The full list is on the Dupilumab page.
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