Drug interactions
Dutasteride-tamsulosin + Duvelisib
Severity: Moderate
Dutasteride-tamsulosin and Duvelisib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Duvelisib inhibits CYP3A4 and can raise tamsulosin and dutasteride concentrations. Higher tamsulosin exposure may cause dizziness and orthostatic hypotension.
What this interaction means in plain words
Dutasteride-tamsulosin and Duvelisib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dutasteride-tamsulosin belongs to Genitourinary; Duvelisib belongs to Oncology.
Why it happens
Inhibition of CYP3A4 by duvelisib reduces metabolism of tamsulosin and dutasteride.
What to do
Monitor for orthostatic hypotension and other adverse effects of tamsulosin. Consider a lower tamsulosin dose or an alternative if symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dutasteride-tamsulosin
Other interactions of Duvelisib
- Duvelisib + Ergotamine Contraindicated
- Alfuzosin + Duvelisib Major
- Apalutamide + Duvelisib Major
- Avanafil + Duvelisib Major
- Carbamazepine + Duvelisib Major
- Chloramphenicol + Duvelisib Major
Frequently asked questions
Can I take Dutasteride-tamsulosin with Duvelisib?
MediHelp rates the interaction as moderate. Dutasteride-tamsulosin and Duvelisib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Duvelisib inhibits CYP3A4 and can raise tamsulosin and dutasteride concentrations. Higher tamsulosin exposure may cause dizziness and orthostatic hypotension.
How serious is the interaction between Dutasteride-tamsulosin and Duvelisib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for orthostatic hypotension and other adverse effects of tamsulosin. Consider a lower tamsulosin dose or an alternative if symptoms occur.
What other medicines interact with Dutasteride-tamsulosin?
MediHelp also lists interactions of Dutasteride-tamsulosin with, for example, Alfuzosin, Amifostine, Atazanavir. The full list is on the Dutasteride-tamsulosin page.
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