Drug interactions
Dutasteride-tamsulosin + Fluoxetine
Severity: Moderate
Dutasteride-tamsulosin and Fluoxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoxetine is a strong CYP2D6 inhibitor and can considerably raise tamsulosin concentrations. This increases the risk of dizziness, orthostatic hypotension and syncope.
What this interaction means in plain words
Dutasteride-tamsulosin and Fluoxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dutasteride-tamsulosin belongs to Genitourinary; Fluoxetine belongs to Central Nervous System.
Why it happens
Fluoxetine and norfluoxetine inhibit CYP2D6, reducing tamsulosin metabolism.
What to do
Use caution and monitor blood pressure and orthostatic symptoms. Consider a lower tamsulosin dose, and note the effect persists for weeks after stopping fluoxetine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dutasteride-tamsulosin and Fluoxetine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Dutasteride-tamsulosin
Other interactions of Fluoxetine
- Fluoxetine + Isocarboxazid Contraindicated
- Fluoxetine + Mavacamten Contraindicated
- Fluoxetine + Methylene blue Contraindicated
- Fluoxetine + Phenelzine Contraindicated
- Fluoxetine + Pimozide Contraindicated
- Fluoxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Dutasteride-tamsulosin with Fluoxetine?
MediHelp rates the interaction as moderate. Dutasteride-tamsulosin and Fluoxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluoxetine is a strong CYP2D6 inhibitor and can considerably raise tamsulosin concentrations. This increases the risk of dizziness, orthostatic hypotension and syncope.
How serious is the interaction between Dutasteride-tamsulosin and Fluoxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use caution and monitor blood pressure and orthostatic symptoms. Consider a lower tamsulosin dose, and note the effect persists for weeks after stopping fluoxetine.
What other medicines interact with Dutasteride-tamsulosin?
MediHelp also lists interactions of Dutasteride-tamsulosin with, for example, Alfuzosin, Amifostine, Atazanavir. The full list is on the Dutasteride-tamsulosin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
