Drug interactions
Dutasteride-tamsulosin + Imatinib
Severity: Moderate
Dutasteride-tamsulosin and Imatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imatinib is a moderate CYP3A4 inhibitor and may raise tamsulosin and dutasteride concentrations. This could increase hypotension and dizziness.
What this interaction means in plain words
Dutasteride-tamsulosin and Imatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dutasteride-tamsulosin belongs to Genitourinary; Imatinib belongs to Oncology.
Why it happens
Inhibition of CYP3A4 reduces clearance of tamsulosin and dutasteride.
What to do
Monitor blood pressure and orthostatic symptoms, particularly at initiation. Reduce or stop tamsulosin if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dutasteride-tamsulosin
Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Frequently asked questions
Can I take Dutasteride-tamsulosin with Imatinib?
MediHelp rates the interaction as moderate. Dutasteride-tamsulosin and Imatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Imatinib is a moderate CYP3A4 inhibitor and may raise tamsulosin and dutasteride concentrations. This could increase hypotension and dizziness.
How serious is the interaction between Dutasteride-tamsulosin and Imatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms, particularly at initiation. Reduce or stop tamsulosin if symptomatic hypotension occurs.
What other medicines interact with Dutasteride-tamsulosin?
MediHelp also lists interactions of Dutasteride-tamsulosin with, for example, Alfuzosin, Amifostine, Atazanavir. The full list is on the Dutasteride-tamsulosin page.
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