Drug interactions
Dutasteride-tamsulosin + Lapatinib
Severity: Moderate
Dutasteride-tamsulosin and Lapatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lapatinib is a weak-to-moderate CYP3A4 inhibitor and may increase exposure to tamsulosin and dutasteride, both CYP3A4 substrates. Higher tamsulosin levels can cause more dizziness and hypotension.
What this interaction means in plain words
Dutasteride-tamsulosin and Lapatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dutasteride-tamsulosin belongs to Genitourinary; Lapatinib belongs to Oncology.
Why it happens
Inhibition of intestinal and hepatic CYP3A4 reduces clearance of tamsulosin and dutasteride.
What to do
Monitor for orthostatic hypotension and dizziness during lapatinib therapy. Consider an alternative if symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dutasteride-tamsulosin and Lapatinib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Dutasteride-tamsulosin
Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Frequently asked questions
Can I take Dutasteride-tamsulosin with Lapatinib?
MediHelp rates the interaction as moderate. Dutasteride-tamsulosin and Lapatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lapatinib is a weak-to-moderate CYP3A4 inhibitor and may increase exposure to tamsulosin and dutasteride, both CYP3A4 substrates. Higher tamsulosin levels can cause more dizziness and hypotension.
How serious is the interaction between Dutasteride-tamsulosin and Lapatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for orthostatic hypotension and dizziness during lapatinib therapy. Consider an alternative if symptoms occur.
What other medicines interact with Dutasteride-tamsulosin?
MediHelp also lists interactions of Dutasteride-tamsulosin with, for example, Alfuzosin, Amifostine, Atazanavir. The full list is on the Dutasteride-tamsulosin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
