Drug interactions
Dutasteride-tamsulosin + Lenacapavir
Severity: Moderate
Dutasteride-tamsulosin and Lenacapavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lenacapavir is a moderate CYP3A inhibitor with a very long duration of effect after subcutaneous dosing. It may raise tamsulosin and dutasteride exposure for months. This may increase dizziness and orthostatic hypotension.
What this interaction means in plain words
Dutasteride-tamsulosin and Lenacapavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dutasteride-tamsulosin belongs to Genitourinary; Lenacapavir belongs to Anti Virals.
Why it happens
Lenacapavir inhibits CYP3A4, reducing tamsulosin and dutasteride clearance.
What to do
Monitor blood pressure and orthostatic symptoms when starting tamsulosin or after lenacapavir. Reduce the tamsulosin dose if adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dutasteride-tamsulosin
Other interactions of Lenacapavir
- Apalutamide + Lenacapavir Contraindicated
- Carbamazepine + Lenacapavir Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
- Flibanserin + Lenacapavir Contraindicated
- Lenacapavir + Phenytoin Contraindicated
- Lenacapavir + Rifampicin Contraindicated
Frequently asked questions
Can I take Dutasteride-tamsulosin with Lenacapavir?
MediHelp rates the interaction as moderate. Dutasteride-tamsulosin and Lenacapavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lenacapavir is a moderate CYP3A inhibitor with a very long duration of effect after subcutaneous dosing. It may raise tamsulosin and dutasteride exposure for months. This may increase dizziness and orthostatic hypotension.
How serious is the interaction between Dutasteride-tamsulosin and Lenacapavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms when starting tamsulosin or after lenacapavir. Reduce the tamsulosin dose if adverse effects occur.
What other medicines interact with Dutasteride-tamsulosin?
MediHelp also lists interactions of Dutasteride-tamsulosin with, for example, Alfuzosin, Amifostine, Atazanavir. The full list is on the Dutasteride-tamsulosin page.
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