Drug interactions
Dutasteride-tamsulosin + Mifepristone
Severity: Major
Dutasteride-tamsulosin and Mifepristone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone is a strong CYP3A4 inhibitor and can substantially raise exposure to tamsulosin and dutasteride. Increased tamsulosin levels can lead to symptomatic hypotension and syncope.
What this interaction means in plain words
Dutasteride-tamsulosin and Mifepristone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dutasteride-tamsulosin belongs to Genitourinary; Mifepristone belongs to Endocrine.
Why it happens
Strong inhibition of CYP3A4 reduces clearance of tamsulosin and dutasteride.
What to do
Avoid concurrent use where possible; if unavoidable, monitor blood pressure and orthostatic symptoms closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Dutasteride-tamsulosin
Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Frequently asked questions
Can I take Dutasteride-tamsulosin with Mifepristone?
MediHelp rates the interaction as major. Dutasteride-tamsulosin and Mifepristone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Mifepristone is a strong CYP3A4 inhibitor and can substantially raise exposure to tamsulosin and dutasteride. Increased tamsulosin levels can lead to symptomatic hypotension and syncope.
How serious is the interaction between Dutasteride-tamsulosin and Mifepristone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where possible; if unavoidable, monitor blood pressure and orthostatic symptoms closely.
What other medicines interact with Dutasteride-tamsulosin?
MediHelp also lists interactions of Dutasteride-tamsulosin with, for example, Alfuzosin, Amifostine, Atazanavir. The full list is on the Dutasteride-tamsulosin page.
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