Drug interactions
Dutasteride-tamsulosin + Mitotane
Severity: Moderate
Dutasteride-tamsulosin and Mitotane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mitotane is a strong CYP3A4 inducer that can substantially lower tamsulosin and dutasteride concentrations. This may lead to loss of symptom control in benign prostatic hyperplasia. The induction persists for weeks after mitotane is stopped.
What this interaction means in plain words
Dutasteride-tamsulosin and Mitotane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dutasteride-tamsulosin belongs to Genitourinary; Mitotane belongs to Oncology.
Why it happens
Mitotane induces CYP3A4, increasing the metabolism of tamsulosin and dutasteride.
What to do
Monitor urinary symptom response and consider a higher tamsulosin dose or alternative therapy. Reassess after mitotane is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dutasteride-tamsulosin
Other interactions of Mitotane
- Doravirine + Mitotane Contraindicated
- Fostemsavir + Mitotane Contraindicated
- Lorlatinib + Mitotane Contraindicated
- Abiraterone + Mitotane Major
- Apixaban + Mitotane Major
- Aprepitant + Mitotane Major
Frequently asked questions
Can I take Dutasteride-tamsulosin with Mitotane?
MediHelp rates the interaction as moderate. Dutasteride-tamsulosin and Mitotane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mitotane is a strong CYP3A4 inducer that can substantially lower tamsulosin and dutasteride concentrations. This may lead to loss of symptom control in benign prostatic hyperplasia. The induction persists for weeks after mitotane is stopped.
How serious is the interaction between Dutasteride-tamsulosin and Mitotane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor urinary symptom response and consider a higher tamsulosin dose or alternative therapy. Reassess after mitotane is stopped.
What other medicines interact with Dutasteride-tamsulosin?
MediHelp also lists interactions of Dutasteride-tamsulosin with, for example, Alfuzosin, Amifostine, Atazanavir. The full list is on the Dutasteride-tamsulosin page.
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