Drug interactions
Dutasteride-tamsulosin + Nicardipine
Severity: Moderate
Dutasteride-tamsulosin and Nicardipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nicardipine weakly inhibits CYP3A4 and is itself a vasodilator, so combined use may add to the blood-pressure-lowering effect of tamsulosin. The pharmacokinetic effect is usually modest.
What this interaction means in plain words
Dutasteride-tamsulosin and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dutasteride-tamsulosin belongs to Genitourinary; Nicardipine belongs to Cardiovascular.
Why it happens
Additive vasodilation plus possible weak CYP3A4 inhibition.
What to do
Monitor blood pressure and orthostatic symptoms when starting or changing doses of either drug.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dutasteride-tamsulosin
Other interactions of Nicardipine
Frequently asked questions
Can I take Dutasteride-tamsulosin with Nicardipine?
MediHelp rates the interaction as moderate. Dutasteride-tamsulosin and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nicardipine weakly inhibits CYP3A4 and is itself a vasodilator, so combined use may add to the blood-pressure-lowering effect of tamsulosin. The pharmacokinetic effect is usually modest.
How serious is the interaction between Dutasteride-tamsulosin and Nicardipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms when starting or changing doses of either drug.
What other medicines interact with Dutasteride-tamsulosin?
MediHelp also lists interactions of Dutasteride-tamsulosin with, for example, Alfuzosin, Amifostine, Atazanavir. The full list is on the Dutasteride-tamsulosin page.
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