Drug interactions
Dutasteride-tamsulosin + Ritonavir
Severity: Major
Dutasteride-tamsulosin and Ritonavir: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritonavir is a strong CYP3A4 and CYP2D6 inhibitor and can markedly increase tamsulosin exposure. This may cause severe orthostatic hypotension and syncope.
What this interaction means in plain words
Dutasteride-tamsulosin and Ritonavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dutasteride-tamsulosin belongs to Genitourinary; Ritonavir belongs to Anti Virals.
Why it happens
Ritonavir inhibits CYP3A4 and CYP2D6, reducing tamsulosin clearance.
What to do
Avoid if possible and use an alternative BPH therapy. If combined, monitor blood pressure and counsel on orthostatic symptoms.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Dutasteride-tamsulosin
Other interactions of Ritonavir
- Alfuzosin + Ritonavir Contraindicated
- Amiodarone + Ritonavir Contraindicated
- Avanafil + Ritonavir Contraindicated
- Colchicine + Ritonavir Contraindicated
- Dronedarone + Ritonavir Contraindicated
- Eletriptan + Ritonavir Contraindicated
Frequently asked questions
Can I take Dutasteride-tamsulosin with Ritonavir?
MediHelp rates the interaction as major. Dutasteride-tamsulosin and Ritonavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ritonavir is a strong CYP3A4 and CYP2D6 inhibitor and can markedly increase tamsulosin exposure. This may cause severe orthostatic hypotension and syncope.
How serious is the interaction between Dutasteride-tamsulosin and Ritonavir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible and use an alternative BPH therapy. If combined, monitor blood pressure and counsel on orthostatic symptoms.
What other medicines interact with Dutasteride-tamsulosin?
MediHelp also lists interactions of Dutasteride-tamsulosin with, for example, Alfuzosin, Amifostine, Atazanavir. The full list is on the Dutasteride-tamsulosin page.
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