Drug interactions
Dutasteride-tamsulosin + Secobarbital
Severity: Moderate
Dutasteride-tamsulosin and Secobarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Secobarbital, a barbiturate, induces hepatic enzymes including CYP3A4 and may lower tamsulosin and dutasteride exposure. Symptom control may be reduced.
What this interaction means in plain words
Dutasteride-tamsulosin and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dutasteride-tamsulosin belongs to Genitourinary; Secobarbital belongs to Central Nervous System.
Why it happens
Enzyme induction by barbiturates increases metabolism of tamsulosin and dutasteride.
What to do
Monitor urinary symptom response and adjust therapy if efficacy is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dutasteride-tamsulosin
Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Frequently asked questions
Can I take Dutasteride-tamsulosin with Secobarbital?
MediHelp rates the interaction as moderate. Dutasteride-tamsulosin and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Secobarbital, a barbiturate, induces hepatic enzymes including CYP3A4 and may lower tamsulosin and dutasteride exposure. Symptom control may be reduced.
How serious is the interaction between Dutasteride-tamsulosin and Secobarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor urinary symptom response and adjust therapy if efficacy is lost.
What other medicines interact with Dutasteride-tamsulosin?
MediHelp also lists interactions of Dutasteride-tamsulosin with, for example, Alfuzosin, Amifostine, Atazanavir. The full list is on the Dutasteride-tamsulosin page.
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