Drug interactions
Duvelisib + Eltrombopag
Severity: Moderate
Duvelisib and Eltrombopag: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Duvelisib is a BCRP substrate, and eltrombopag inhibits BCRP. Duvelisib exposure may rise, increasing risks such as diarrhea, infection and hepatotoxicity.
What this interaction means in plain words
Duvelisib and Eltrombopag can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Duvelisib belongs to Oncology; Eltrombopag belongs to Miscellaneous.
Why it happens
Eltrombopag inhibits intestinal BCRP efflux, which may increase duvelisib absorption.
What to do
Monitor for duvelisib toxicity, including diarrhea, rash and liver enzyme elevations. Interrupt or reduce the duvelisib dose according to labeling if toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eltrombopag
- Alpelisib + Eltrombopag Moderate
- Aluminum hydroxide + Eltrombopag Moderate
- Amobarbital + Eltrombopag Moderate
- Artesunate + Eltrombopag Moderate
- Atazanavir + Eltrombopag Moderate
- Atorvastatin + Eltrombopag Moderate
Other interactions of Duvelisib
- Duvelisib + Ergotamine Contraindicated
- Alfuzosin + Duvelisib Major
- Apalutamide + Duvelisib Major
- Avanafil + Duvelisib Major
- Carbamazepine + Duvelisib Major
- Chloramphenicol + Duvelisib Major
Frequently asked questions
Can I take Duvelisib with Eltrombopag?
MediHelp rates the interaction as moderate. Duvelisib and Eltrombopag can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Duvelisib is a BCRP substrate, and eltrombopag inhibits BCRP. Duvelisib exposure may rise, increasing risks such as diarrhea, infection and hepatotoxicity.
How serious is the interaction between Duvelisib and Eltrombopag?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for duvelisib toxicity, including diarrhea, rash and liver enzyme elevations. Interrupt or reduce the duvelisib dose according to labeling if toxicity occurs.
What other medicines interact with Eltrombopag?
MediHelp also lists interactions of Eltrombopag with, for example, Alpelisib, Aluminum hydroxide, Amobarbital. The full list is on the Eltrombopag page.
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