Drug interactions
Duvelisib + Eszopiclone
Severity: Moderate
Duvelisib and Eszopiclone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Duvelisib inhibits CYP3A4 and increases exposure to sensitive substrates such as eszopiclone. Higher eszopiclone levels may produce more sedation and psychomotor impairment.
What this interaction means in plain words
Duvelisib and Eszopiclone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Duvelisib belongs to Oncology; Eszopiclone belongs to Central Nervous System.
Why it happens
Duvelisib inhibits CYP3A4-mediated eszopiclone metabolism.
What to do
Reduce the eszopiclone dose (start at 1 mg) and monitor for excessive sedation and next-day impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eszopiclone
Other interactions of Duvelisib
- Duvelisib + Ergotamine Contraindicated
- Alfuzosin + Duvelisib Major
- Apalutamide + Duvelisib Major
- Avanafil + Duvelisib Major
- Carbamazepine + Duvelisib Major
- Chloramphenicol + Duvelisib Major
Frequently asked questions
Can I take Duvelisib with Eszopiclone?
MediHelp rates the interaction as moderate. Duvelisib and Eszopiclone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Duvelisib inhibits CYP3A4 and increases exposure to sensitive substrates such as eszopiclone. Higher eszopiclone levels may produce more sedation and psychomotor impairment.
How serious is the interaction between Duvelisib and Eszopiclone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the eszopiclone dose (start at 1 mg) and monitor for excessive sedation and next-day impairment.
What other medicines interact with Eszopiclone?
MediHelp also lists interactions of Eszopiclone with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Amobarbital. The full list is on the Eszopiclone page.
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