Drug interactions
Duvelisib + Imatinib
Severity: Major
Duvelisib and Imatinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Duvelisib inhibits CYP3A4 and can increase imatinib exposure, while imatinib may inhibit BCRP and CYP3A4 and raise duvelisib levels. Both drugs may therefore have greater toxicity, including cytopenias and infection.
What this interaction means in plain words
Duvelisib and Imatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Duvelisib belongs to Oncology; Imatinib belongs to Oncology.
Why it happens
Duvelisib inhibits CYP3A4, and imatinib inhibits CYP3A4 and BCRP, reducing clearance of each drug.
What to do
Reduce the imatinib dose where appropriate, and monitor blood counts, infection and liver tests. Reduce the duvelisib dose if toxicity develops.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Other interactions of Duvelisib
- Duvelisib + Ergotamine Contraindicated
- Alfuzosin + Duvelisib Major
- Apalutamide + Duvelisib Major
- Avanafil + Duvelisib Major
- Carbamazepine + Duvelisib Major
- Chloramphenicol + Duvelisib Major
Frequently asked questions
Can I take Duvelisib with Imatinib?
MediHelp rates the interaction as major. Duvelisib and Imatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Duvelisib inhibits CYP3A4 and can increase imatinib exposure, while imatinib may inhibit BCRP and CYP3A4 and raise duvelisib levels. Both drugs may therefore have greater toxicity, including cytopenias and infection.
How serious is the interaction between Duvelisib and Imatinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the imatinib dose where appropriate, and monitor blood counts, infection and liver tests. Reduce the duvelisib dose if toxicity develops.
What other medicines interact with Imatinib?
MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Lonafarnib, Amobarbital. The full list is on the Imatinib page.
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