Drug interactions
Duvelisib + Lidocaine-prilocaine
Severity: Minor
Duvelisib and Lidocaine-prilocaine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Duvelisib inhibits CYP3A4 and may raise lidocaine concentrations. With topical lidocaine-prilocaine at usual doses, systemic exposure is small so the clinical impact is likely limited, but it matters more with large-area or repeated use.
What this interaction means in plain words
Duvelisib and Lidocaine-prilocaine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Duvelisib belongs to Oncology; Lidocaine-prilocaine belongs to Genitourinary.
Why it happens
Duvelisib inhibits CYP3A4, reducing the metabolism of lidocaine.
What to do
Use usual topical amounts on limited areas and avoid extensive or occluded application. Monitor for lidocaine toxicity such as dizziness or arrhythmia if large doses are used.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lidocaine-prilocaine
- Lidocaine-prilocaine + Phenazopyridine Major
- Bupivacaine implant + Lidocaine-prilocaine Moderate
- Bupivacaine liposome + Lidocaine-prilocaine Moderate
- Disopyramide + Lidocaine-prilocaine Moderate
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Lidocaine-prilocaine Moderate
- Lidocaine-prilocaine + Mexiletine Moderate
Other interactions of Duvelisib
- Duvelisib + Ergotamine Contraindicated
- Alfuzosin + Duvelisib Major
- Apalutamide + Duvelisib Major
- Avanafil + Duvelisib Major
- Carbamazepine + Duvelisib Major
- Chloramphenicol + Duvelisib Major
Frequently asked questions
Can I take Duvelisib with Lidocaine-prilocaine?
MediHelp rates the interaction as minor. Duvelisib and Lidocaine-prilocaine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Duvelisib inhibits CYP3A4 and may raise lidocaine concentrations. With topical lidocaine-prilocaine at usual doses, systemic exposure is small so the clinical impact is likely limited, but it matters more with large-area or repeated use.
How serious is the interaction between Duvelisib and Lidocaine-prilocaine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use usual topical amounts on limited areas and avoid extensive or occluded application. Monitor for lidocaine toxicity such as dizziness or arrhythmia if large doses are used.
What other medicines interact with Lidocaine-prilocaine?
MediHelp also lists interactions of Lidocaine-prilocaine with, for example, Phenazopyridine, Bupivacaine implant, Bupivacaine liposome. The full list is on the Lidocaine-prilocaine page.
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