Drug interactions
Duvelisib + Mifepristone
Severity: Major
Duvelisib and Mifepristone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone can raise duvelisib exposure via CYP3A4 inhibition, and duvelisib can in turn increase exposure of CYP3A4 substrates like mifepristone. This raises the risk of duvelisib toxicities such as infections, diarrhea and skin reactions, and of mifepristone adverse effects.
What this interaction means in plain words
Duvelisib and Mifepristone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Duvelisib belongs to Oncology; Mifepristone belongs to Endocrine.
Why it happens
Bidirectional CYP3A4 interaction: mifepristone inhibits duvelisib metabolism and duvelisib inhibits CYP3A4 substrate clearance.
What to do
Reduce duvelisib to 15 mg twice daily during mifepristone use, and monitor for infections and cutaneous toxicity. Monitor for mifepristone adverse effects such as hypokalemia and QT prolongation.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Other interactions of Duvelisib
- Duvelisib + Ergotamine Contraindicated
- Alfuzosin + Duvelisib Major
- Apalutamide + Duvelisib Major
- Avanafil + Duvelisib Major
- Carbamazepine + Duvelisib Major
- Chloramphenicol + Duvelisib Major
Frequently asked questions
Can I take Duvelisib with Mifepristone?
MediHelp rates the interaction as major. Duvelisib and Mifepristone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Mifepristone can raise duvelisib exposure via CYP3A4 inhibition, and duvelisib can in turn increase exposure of CYP3A4 substrates like mifepristone. This raises the risk of duvelisib toxicities such as infections, diarrhea and skin reactions, and of mifepristone adverse effects.
How serious is the interaction between Duvelisib and Mifepristone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce duvelisib to 15 mg twice daily during mifepristone use, and monitor for infections and cutaneous toxicity. Monitor for mifepristone adverse effects such as hypokalemia and QT prolongation.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
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