Drug interactions
Duvelisib + Nimodipine
Severity: Major
Duvelisib and Nimodipine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Duvelisib inhibits CYP3A4 and can raise nimodipine levels, increasing the risk of hypotension, flushing, headache and edema. Nimodipine is highly dependent on CYP3A4 for first-pass metabolism, so the effect may be marked.
What this interaction means in plain words
Duvelisib and Nimodipine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Duvelisib belongs to Oncology; Nimodipine belongs to Cardiovascular.
Why it happens
Duvelisib inhibits CYP3A4, decreasing nimodipine first-pass and systemic metabolism.
What to do
Monitor blood pressure closely and consider reducing the nimodipine dose, for example by splitting it into smaller more frequent doses.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Nimodipine
- Apalutamide + Nimodipine Major
- Carbamazepine + Nimodipine Major
- Ceritinib + Nimodipine Major
- Clarithromycin + Nimodipine Major
- Cobicistat + Nimodipine Major
- Darunavir + Nimodipine Major
Other interactions of Duvelisib
- Duvelisib + Ergotamine Contraindicated
- Alfuzosin + Duvelisib Major
- Apalutamide + Duvelisib Major
- Avanafil + Duvelisib Major
- Carbamazepine + Duvelisib Major
- Chloramphenicol + Duvelisib Major
Frequently asked questions
Can I take Duvelisib with Nimodipine?
MediHelp rates the interaction as major. Duvelisib and Nimodipine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Duvelisib inhibits CYP3A4 and can raise nimodipine levels, increasing the risk of hypotension, flushing, headache and edema. Nimodipine is highly dependent on CYP3A4 for first-pass metabolism, so the effect may be marked.
How serious is the interaction between Duvelisib and Nimodipine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure closely and consider reducing the nimodipine dose, for example by splitting it into smaller more frequent doses.
What other medicines interact with Nimodipine?
MediHelp also lists interactions of Nimodipine with, for example, Apalutamide, Carbamazepine, Ceritinib. The full list is on the Nimodipine page.
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