Drug interactions
Duvelisib + Paclitaxel
Severity: Moderate
Duvelisib and Paclitaxel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Duvelisib inhibits CYP3A4 and may increase exposure to paclitaxel, which is partly cleared by this enzyme. This may worsen myelosuppression and neuropathy.
What this interaction means in plain words
Duvelisib and Paclitaxel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Duvelisib belongs to Oncology; Paclitaxel belongs to Oncology.
Why it happens
Duvelisib inhibits CYP3A4, reducing paclitaxel metabolism.
What to do
Monitor blood counts and neurological toxicity and reduce the paclitaxel dose if adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Paclitaxel
Other interactions of Duvelisib
- Duvelisib + Ergotamine Contraindicated
- Alfuzosin + Duvelisib Major
- Apalutamide + Duvelisib Major
- Avanafil + Duvelisib Major
- Carbamazepine + Duvelisib Major
- Chloramphenicol + Duvelisib Major
Frequently asked questions
Can I take Duvelisib with Paclitaxel?
MediHelp rates the interaction as moderate. Duvelisib and Paclitaxel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Duvelisib inhibits CYP3A4 and may increase exposure to paclitaxel, which is partly cleared by this enzyme. This may worsen myelosuppression and neuropathy.
How serious is the interaction between Duvelisib and Paclitaxel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and neurological toxicity and reduce the paclitaxel dose if adverse effects occur.
What other medicines interact with Paclitaxel?
MediHelp also lists interactions of Paclitaxel with, for example, Adenovirus types 4 and 7 live, Cobicistat, Cyclosporin. The full list is on the Paclitaxel page.
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