Drug interactions
Duvelisib + Propafenone
Severity: Minor
Duvelisib and Propafenone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propafenone may inhibit P-glycoprotein and increase duvelisib exposure. Clinical significance is uncertain, but higher duvelisib levels could increase its toxicity, including infection, diarrhea and skin reactions.
What this interaction means in plain words
Duvelisib and Propafenone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Duvelisib belongs to Oncology; Propafenone belongs to Cardiovascular.
Why it happens
Possible P-glycoprotein inhibition by propafenone raising duvelisib absorption.
What to do
Monitor for duvelisib adverse effects such as diarrhea, rash and infection. Adjust the duvelisib dose according to toxicity.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Propafenone
- Dofetilide + Propafenone Contraindicated
- Dronedarone + Propafenone Contraindicated
- Nilotinib + Propafenone Contraindicated
- Nirmatrelvir / ritonavir + Propafenone Contraindicated
- Nirmatrelvir + Propafenone Contraindicated
- Pimozide + Propafenone Contraindicated
Other interactions of Duvelisib
- Duvelisib + Ergotamine Contraindicated
- Alfuzosin + Duvelisib Major
- Apalutamide + Duvelisib Major
- Avanafil + Duvelisib Major
- Carbamazepine + Duvelisib Major
- Chloramphenicol + Duvelisib Major
Frequently asked questions
Can I take Duvelisib with Propafenone?
MediHelp rates the interaction as minor. Duvelisib and Propafenone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Propafenone may inhibit P-glycoprotein and increase duvelisib exposure. Clinical significance is uncertain, but higher duvelisib levels could increase its toxicity, including infection, diarrhea and skin reactions.
How serious is the interaction between Duvelisib and Propafenone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for duvelisib adverse effects such as diarrhea, rash and infection. Adjust the duvelisib dose according to toxicity.
What other medicines interact with Propafenone?
MediHelp also lists interactions of Propafenone with, for example, Dofetilide, Dronedarone, Nilotinib. The full list is on the Propafenone page.
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