Drug interactions
Duvelisib + Quetiapine
Severity: Moderate
Duvelisib and Quetiapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Duvelisib inhibits CYP3A4, the main enzyme metabolizing quetiapine, and can raise quetiapine exposure. This may increase sedation, hypotension and QT prolongation.
What this interaction means in plain words
Duvelisib and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Duvelisib belongs to Oncology; Quetiapine belongs to Central Nervous System.
Why it happens
Inhibition of CYP3A4-mediated quetiapine metabolism.
What to do
Consider reducing the quetiapine dose and monitor for sedation, orthostatic hypotension and QT changes. Restore the dose after duvelisib is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Other interactions of Duvelisib
- Duvelisib + Ergotamine Contraindicated
- Alfuzosin + Duvelisib Major
- Apalutamide + Duvelisib Major
- Avanafil + Duvelisib Major
- Carbamazepine + Duvelisib Major
- Chloramphenicol + Duvelisib Major
Frequently asked questions
Can I take Duvelisib with Quetiapine?
MediHelp rates the interaction as moderate. Duvelisib and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Duvelisib inhibits CYP3A4, the main enzyme metabolizing quetiapine, and can raise quetiapine exposure. This may increase sedation, hypotension and QT prolongation.
How serious is the interaction between Duvelisib and Quetiapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the quetiapine dose and monitor for sedation, orthostatic hypotension and QT changes. Restore the dose after duvelisib is stopped.
What other medicines interact with Quetiapine?
MediHelp also lists interactions of Quetiapine with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Quetiapine page.
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