Drug interactions
Duvelisib + Saxagliptin-metformin
Severity: Moderate
Duvelisib and Saxagliptin-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Duvelisib inhibits CYP3A4 and may increase saxagliptin exposure, raising the chance of saxagliptin adverse effects. The clinical impact is not well characterized.
What this interaction means in plain words
Duvelisib and Saxagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Duvelisib belongs to Oncology; Saxagliptin-metformin belongs to Endocrine.
Why it happens
Duvelisib inhibits CYP3A4, reducing saxagliptin metabolism.
What to do
Monitor for saxagliptin adverse effects and consider limiting saxagliptin to 2.5 mg daily.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Saxagliptin-metformin
Other interactions of Duvelisib
- Duvelisib + Ergotamine Contraindicated
- Alfuzosin + Duvelisib Major
- Apalutamide + Duvelisib Major
- Avanafil + Duvelisib Major
- Carbamazepine + Duvelisib Major
- Chloramphenicol + Duvelisib Major
Frequently asked questions
Can I take Duvelisib with Saxagliptin-metformin?
MediHelp rates the interaction as moderate. Duvelisib and Saxagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Duvelisib inhibits CYP3A4 and may increase saxagliptin exposure, raising the chance of saxagliptin adverse effects. The clinical impact is not well characterized.
How serious is the interaction between Duvelisib and Saxagliptin-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for saxagliptin adverse effects and consider limiting saxagliptin to 2.5 mg daily.
What other medicines interact with Saxagliptin-metformin?
MediHelp also lists interactions of Saxagliptin-metformin with, for example, Atazanavir, Clozapine, Contrast media. The full list is on the Saxagliptin-metformin page.
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