Drug interactions
Duvelisib + Ticagrelor
Severity: Major
Duvelisib and Ticagrelor: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Duvelisib is a CYP3A4 inhibitor and raises exposure to sensitive CYP3A4 substrates. Ticagrelor is a CYP3A4 substrate, so higher levels may increase bleeding and dyspnea.
What this interaction means in plain words
Duvelisib and Ticagrelor can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Duvelisib belongs to Oncology; Ticagrelor belongs to Cardiovascular.
Why it happens
Duvelisib inhibits CYP3A4, reducing ticagrelor clearance.
What to do
Monitor for bleeding and consider an alternative antiplatelet agent not dependent on CYP3A4. Avoid if bleeding risk is high.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ticagrelor
- Itraconazole + Ticagrelor Contraindicated
- Ketoconazole + Ticagrelor Contraindicated
- Levoketoconazole + Ticagrelor Contraindicated
- Abciximab + Ticagrelor Major
- Abrocitinib + Ticagrelor Major
- Acalabrutinib + Ticagrelor Major
Other interactions of Duvelisib
- Duvelisib + Ergotamine Contraindicated
- Alfuzosin + Duvelisib Major
- Apalutamide + Duvelisib Major
- Avanafil + Duvelisib Major
- Carbamazepine + Duvelisib Major
- Chloramphenicol + Duvelisib Major
Frequently asked questions
Can I take Duvelisib with Ticagrelor?
MediHelp rates the interaction as major. Duvelisib and Ticagrelor can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Duvelisib is a CYP3A4 inhibitor and raises exposure to sensitive CYP3A4 substrates. Ticagrelor is a CYP3A4 substrate, so higher levels may increase bleeding and dyspnea.
How serious is the interaction between Duvelisib and Ticagrelor?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and consider an alternative antiplatelet agent not dependent on CYP3A4. Avoid if bleeding risk is high.
What other medicines interact with Ticagrelor?
MediHelp also lists interactions of Ticagrelor with, for example, Itraconazole, Ketoconazole, Levoketoconazole. The full list is on the Ticagrelor page.
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