Drug interactions
Duvelisib + Verapamil
Severity: Major
Duvelisib and Verapamil: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Duvelisib inhibits CYP3A4 and can substantially increase exposure to CYP3A4 substrates such as verapamil, risking hypotension, bradycardia and AV block. Verapamil may in turn raise duvelisib levels.
What this interaction means in plain words
Duvelisib and Verapamil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Duvelisib belongs to Oncology; Verapamil belongs to Cardiovascular.
Why it happens
Duvelisib inhibits CYP3A4, and verapamil as a CYP3A4/P-gp inhibitor can increase duvelisib exposure.
What to do
Consider reducing the verapamil dose and monitor heart rate, blood pressure and ECG. Monitor for duvelisib toxicities such as infections, diarrhea and skin reactions.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Other interactions of Duvelisib
- Duvelisib + Ergotamine Contraindicated
- Alfuzosin + Duvelisib Major
- Apalutamide + Duvelisib Major
- Avanafil + Duvelisib Major
- Carbamazepine + Duvelisib Major
- Chloramphenicol + Duvelisib Major
Frequently asked questions
Can I take Duvelisib with Verapamil?
MediHelp rates the interaction as major. Duvelisib and Verapamil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Duvelisib inhibits CYP3A4 and can substantially increase exposure to CYP3A4 substrates such as verapamil, risking hypotension, bradycardia and AV block. Verapamil may in turn raise duvelisib levels.
How serious is the interaction between Duvelisib and Verapamil?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the verapamil dose and monitor heart rate, blood pressure and ECG. Monitor for duvelisib toxicities such as infections, diarrhea and skin reactions.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
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