Drug interactions
Eculizumab + Upadacitinib
Severity: Moderate
Eculizumab and Upadacitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eculizumab raises the risk of serious meningococcal and other encapsulated bacterial infections. Adding upadacitinib may add to infection risk, though data are limited.
What this interaction means in plain words
Eculizumab and Upadacitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eculizumab belongs to Miscellaneous; Upadacitinib belongs to Musculoskeletal.
Why it happens
Additive immunosuppression from complement C5 inhibition and JAK inhibition.
What to do
Ensure meningococcal vaccination and prophylaxis as per eculizumab labeling, and monitor for infection.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Upadacitinib
- Abrocitinib + Upadacitinib Contraindicated
- Adenovirus types 4 and 7 live + Upadacitinib Contraindicated
- Baricitinib + Upadacitinib Contraindicated
- Bcg vaccine live + Upadacitinib Contraindicated
- Cyclosporine + Upadacitinib Contraindicated
- Dengue vaccine + Upadacitinib Contraindicated
Other interactions of Eculizumab
- Crovalimab + Eculizumab Major
Frequently asked questions
Can I take Eculizumab with Upadacitinib?
MediHelp rates the interaction as moderate. Eculizumab and Upadacitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eculizumab raises the risk of serious meningococcal and other encapsulated bacterial infections. Adding upadacitinib may add to infection risk, though data are limited.
How serious is the interaction between Eculizumab and Upadacitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ensure meningococcal vaccination and prophylaxis as per eculizumab labeling, and monitor for infection.
What other medicines interact with Upadacitinib?
MediHelp also lists interactions of Upadacitinib with, for example, Abrocitinib, Adenovirus types 4 and 7 live, Baricitinib. The full list is on the Upadacitinib page.
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