Drug interactions
Edoxaban + Eptifibatide
Severity: Major
Edoxaban and Eptifibatide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eptifibatide blocks the final common pathway of platelet aggregation, and used with edoxaban it markedly raises bleeding risk. Bleeding may be major and involve vascular access sites or the gastrointestinal tract.
What this interaction means in plain words
Edoxaban and Eptifibatide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Edoxaban belongs to Cardiovascular; Eptifibatide belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic effect of glycoprotein IIb/IIIa receptor blockade and factor Xa inhibition.
What to do
Avoid the combination where possible and limit overlap to the infusion period when procedurally necessary. Monitor haemoglobin, platelet count and for signs of bleeding.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Edoxaban
- Apixaban + Edoxaban Contraindicated
- Defibrotide + Edoxaban Contraindicated
- Edoxaban + Ketorolac Contraindicated
- Abciximab + Edoxaban Major
- Acetylsalicylic acid + Edoxaban Major
- Argatroban + Edoxaban Major
Other interactions of Eptifibatide
Frequently asked questions
Can I take Edoxaban with Eptifibatide?
MediHelp rates the interaction as major. Edoxaban and Eptifibatide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Eptifibatide blocks the final common pathway of platelet aggregation, and used with edoxaban it markedly raises bleeding risk. Bleeding may be major and involve vascular access sites or the gastrointestinal tract.
How serious is the interaction between Edoxaban and Eptifibatide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and limit overlap to the infusion period when procedurally necessary. Monitor haemoglobin, platelet count and for signs of bleeding.
What other medicines interact with Edoxaban?
MediHelp also lists interactions of Edoxaban with, for example, Apixaban, Defibrotide, Ketorolac. The full list is on the Edoxaban page.
Full monographs, dosing and an interaction checker in the MediHelp app
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