Drug interactions
Edoxaban + Erdafitinib
Severity: Moderate
Edoxaban and Erdafitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erdafitinib inhibits P-glycoprotein and may increase concentrations of P-gp substrates such as edoxaban, with greater bleeding risk. The effect is predicted from in vitro and mechanistic data.
What this interaction means in plain words
Edoxaban and Erdafitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Edoxaban belongs to Cardiovascular; Erdafitinib belongs to Oncology.
Why it happens
Erdafitinib inhibits intestinal P-glycoprotein, increasing edoxaban absorption.
What to do
If unavoidable, take edoxaban at least 6 hours before or after erdafitinib and monitor for bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Edoxaban
- Apixaban + Edoxaban Contraindicated
- Defibrotide + Edoxaban Contraindicated
- Edoxaban + Ketorolac Contraindicated
- Abciximab + Edoxaban Major
- Acetylsalicylic acid + Edoxaban Major
- Argatroban + Edoxaban Major
Other interactions of Erdafitinib
Frequently asked questions
Can I take Edoxaban with Erdafitinib?
MediHelp rates the interaction as moderate. Edoxaban and Erdafitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Erdafitinib inhibits P-glycoprotein and may increase concentrations of P-gp substrates such as edoxaban, with greater bleeding risk. The effect is predicted from in vitro and mechanistic data.
How serious is the interaction between Edoxaban and Erdafitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If unavoidable, take edoxaban at least 6 hours before or after erdafitinib and monitor for bleeding.
What other medicines interact with Edoxaban?
MediHelp also lists interactions of Edoxaban with, for example, Apixaban, Defibrotide, Ketorolac. The full list is on the Edoxaban page.
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