Drug interactions
Edoxaban + Erythromycin
Severity: Moderate
Edoxaban and Erythromycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin inhibits P-glycoprotein and raises edoxaban exposure, increasing the risk of bleeding. The rise is moderate and the effect is greater in patients with renal impairment or low body weight.
What this interaction means in plain words
Edoxaban and Erythromycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Edoxaban belongs to Cardiovascular; Erythromycin belongs to Anti Bacterial.
Why it happens
Inhibition of P-glycoprotein efflux of edoxaban in the gut and kidney increases its absorption and reduces its clearance.
What to do
For VTE treatment, labeling advises reducing edoxaban to 30 mg once daily with this combination. For atrial fibrillation no dose change is recommended, but monitor for bleeding, especially with renal impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Erythromycin
- Conivaptan + Erythromycin Contraindicated
- Dihydroergotamine intranasal + Erythromycin Contraindicated
- Dihydroergotamine + Erythromycin Contraindicated
- Domperidone + Erythromycin Contraindicated
- Dronedarone + Erythromycin Contraindicated
- Droperidol + Erythromycin Contraindicated
Other interactions of Edoxaban
- Apixaban + Edoxaban Contraindicated
- Defibrotide + Edoxaban Contraindicated
- Edoxaban + Ketorolac Contraindicated
- Abciximab + Edoxaban Major
- Acetylsalicylic acid + Edoxaban Major
- Argatroban + Edoxaban Major
Frequently asked questions
Can I take Edoxaban with Erythromycin?
MediHelp rates the interaction as moderate. Edoxaban and Erythromycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Erythromycin inhibits P-glycoprotein and raises edoxaban exposure, increasing the risk of bleeding. The rise is moderate and the effect is greater in patients with renal impairment or low body weight.
How serious is the interaction between Edoxaban and Erythromycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: For VTE treatment, labeling advises reducing edoxaban to 30 mg once daily with this combination. For atrial fibrillation no dose change is recommended, but monitor for bleeding, especially with renal impairment.
What other medicines interact with Erythromycin?
MediHelp also lists interactions of Erythromycin with, for example, Conivaptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Erythromycin page.
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