Drug interactions
Edoxaban + Istradefylline
Severity: Moderate
Edoxaban and Istradefylline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
At 40 mg/day istradefylline raises exposure to P-gp substrates, which may increase edoxaban levels and bleeding risk. This effect is not expected at 20 mg/day.
What this interaction means in plain words
Edoxaban and Istradefylline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Edoxaban belongs to Cardiovascular; Istradefylline belongs to Central Nervous System.
Why it happens
Dose-dependent inhibition of P-glycoprotein by istradefylline.
What to do
Use istradefylline at 20 mg/day if possible and monitor for bleeding; consider edoxaban dose review if the higher dose is used.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Edoxaban
- Apixaban + Edoxaban Contraindicated
- Defibrotide + Edoxaban Contraindicated
- Edoxaban + Ketorolac Contraindicated
- Abciximab + Edoxaban Major
- Acetylsalicylic acid + Edoxaban Major
- Argatroban + Edoxaban Major
Other interactions of Istradefylline
Frequently asked questions
Can I take Edoxaban with Istradefylline?
MediHelp rates the interaction as moderate. Edoxaban and Istradefylline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. At 40 mg/day istradefylline raises exposure to P-gp substrates, which may increase edoxaban levels and bleeding risk. This effect is not expected at 20 mg/day.
How serious is the interaction between Edoxaban and Istradefylline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use istradefylline at 20 mg/day if possible and monitor for bleeding; consider edoxaban dose review if the higher dose is used.
What other medicines interact with Edoxaban?
MediHelp also lists interactions of Edoxaban with, for example, Apixaban, Defibrotide, Ketorolac. The full list is on the Edoxaban page.
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