Drug interactions
Edoxaban + Meclofenamic acid
Severity: Major
Edoxaban and Meclofenamic acid: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs impair platelet aggregation and can cause gastrointestinal erosion, which adds to the anticoagulant effect of edoxaban. The risk of major and minor bleeding is increased.
What this interaction means in plain words
Edoxaban and Meclofenamic acid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Edoxaban belongs to Cardiovascular; Meclofenamic acid belongs to Musculoskeletal.
Why it happens
Additive pharmacodynamic effect of NSAID platelet inhibition and mucosal injury with factor Xa inhibition.
What to do
Avoid regular NSAID use with edoxaban and use paracetamol for analgesia where feasible. If unavoidable, use the shortest duration, add gastroprotection and monitor for bleeding and hemoglobin.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Meclofenamic acid
- Ketorolac intranasal + Meclofenamic acid Contraindicated
- Ketorolac + Meclofenamic acid Contraindicated
- Aceclofenac + Meclofenamic acid Major
- Acemetacin + Meclofenamic acid Major
- Alteplase + Meclofenamic acid Major
- Amiloride + Meclofenamic acid Major
Other interactions of Edoxaban
- Apixaban + Edoxaban Contraindicated
- Defibrotide + Edoxaban Contraindicated
- Edoxaban + Ketorolac Contraindicated
- Abciximab + Edoxaban Major
- Acetylsalicylic acid + Edoxaban Major
- Argatroban + Edoxaban Major
Frequently asked questions
Can I take Edoxaban with Meclofenamic acid?
MediHelp rates the interaction as major. Edoxaban and Meclofenamic acid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. NSAIDs impair platelet aggregation and can cause gastrointestinal erosion, which adds to the anticoagulant effect of edoxaban. The risk of major and minor bleeding is increased.
How serious is the interaction between Edoxaban and Meclofenamic acid?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid regular NSAID use with edoxaban and use paracetamol for analgesia where feasible. If unavoidable, use the shortest duration, add gastroprotection and monitor for bleeding and hemoglobin.
What other medicines interact with Meclofenamic acid?
MediHelp also lists interactions of Meclofenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meclofenamic acid page.
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