Drug interactions
Edoxaban + Naproxen
Severity: Major
Edoxaban and Naproxen: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Naproxen increases the risk of clinically significant bleeding with edoxaban. Gastrointestinal bleeding is the principal concern.
What this interaction means in plain words
Edoxaban and Naproxen can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Edoxaban belongs to Cardiovascular; Naproxen belongs to Musculoskeletal.
Why it happens
Additive hemostatic impairment from NSAID platelet inhibition and mucosal injury with factor Xa inhibition.
What to do
Avoid chronic NSAID use with edoxaban and use paracetamol for analgesia. If unavoidable, use the lowest NSAID dose briefly, consider gastroprotection and monitor for bleeding.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Naproxen
- Ketorolac intranasal + Naproxen Contraindicated
- Ketorolac + Naproxen Contraindicated
- Aceclofenac + Naproxen Major
- Acemetacin + Naproxen Major
- Acetylsalicylic acid + Naproxen Major
- Alteplase + Naproxen Major
Other interactions of Edoxaban
- Apixaban + Edoxaban Contraindicated
- Defibrotide + Edoxaban Contraindicated
- Edoxaban + Ketorolac Contraindicated
- Abciximab + Edoxaban Major
- Acetylsalicylic acid + Edoxaban Major
- Argatroban + Edoxaban Major
Frequently asked questions
Can I take Edoxaban with Naproxen?
MediHelp rates the interaction as major. Edoxaban and Naproxen can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Naproxen increases the risk of clinically significant bleeding with edoxaban. Gastrointestinal bleeding is the principal concern.
How serious is the interaction between Edoxaban and Naproxen?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid chronic NSAID use with edoxaban and use paracetamol for analgesia. If unavoidable, use the lowest NSAID dose briefly, consider gastroprotection and monitor for bleeding.
What other medicines interact with Naproxen?
MediHelp also lists interactions of Naproxen with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Naproxen page.
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