Drug interactions
Edoxaban + Nelfinavir
Severity: Moderate
Edoxaban and Nelfinavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nelfinavir inhibits P-glycoprotein and may increase edoxaban exposure, raising bleeding risk.
What this interaction means in plain words
Edoxaban and Nelfinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Edoxaban belongs to Cardiovascular; Nelfinavir belongs to Anti Virals.
Why it happens
Nelfinavir inhibits P-glycoprotein, reducing edoxaban efflux and clearance.
What to do
Monitor for bleeding and consider 30 mg daily for DVT/PE; choose an alternative anticoagulant if bleeding risk is high.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Edoxaban
- Apixaban + Edoxaban Contraindicated
- Defibrotide + Edoxaban Contraindicated
- Edoxaban + Ketorolac Contraindicated
- Abciximab + Edoxaban Major
- Acetylsalicylic acid + Edoxaban Major
- Argatroban + Edoxaban Major
Other interactions of Nelfinavir
- Alfuzosin + Nelfinavir Contraindicated
- Avanafil + Nelfinavir Contraindicated
- Dronedarone + Nelfinavir Contraindicated
- Eletriptan + Nelfinavir Contraindicated
- Ergotamine + Nelfinavir Contraindicated
- Flibanserin + Nelfinavir Contraindicated
Frequently asked questions
Can I take Edoxaban with Nelfinavir?
MediHelp rates the interaction as moderate. Edoxaban and Nelfinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nelfinavir inhibits P-glycoprotein and may increase edoxaban exposure, raising bleeding risk.
How serious is the interaction between Edoxaban and Nelfinavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and consider 30 mg daily for DVT/PE; choose an alternative anticoagulant if bleeding risk is high.
What other medicines interact with Edoxaban?
MediHelp also lists interactions of Edoxaban with, for example, Apixaban, Defibrotide, Ketorolac. The full list is on the Edoxaban page.
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