Drug interactions
Edoxaban + Nifedipine
Severity: Minor
Edoxaban and Nifedipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nifedipine is a weak P-glycoprotein inhibitor and may modestly raise edoxaban exposure. The clinical effect is generally small and no routine dose adjustment is recommended.
What this interaction means in plain words
Edoxaban and Nifedipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Edoxaban belongs to Cardiovascular; Nifedipine belongs to Cardiovascular.
Why it happens
Weak inhibition of P-glycoprotein efflux may slightly increase edoxaban absorption.
What to do
No dose change is needed. Remain alert for bleeding, especially in patients with renal impairment or low body weight.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nifedipine
Other interactions of Edoxaban
- Apixaban + Edoxaban Contraindicated
- Defibrotide + Edoxaban Contraindicated
- Edoxaban + Ketorolac Contraindicated
- Abciximab + Edoxaban Major
- Acetylsalicylic acid + Edoxaban Major
- Argatroban + Edoxaban Major
Frequently asked questions
Can I take Edoxaban with Nifedipine?
MediHelp rates the interaction as minor. Edoxaban and Nifedipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nifedipine is a weak P-glycoprotein inhibitor and may modestly raise edoxaban exposure. The clinical effect is generally small and no routine dose adjustment is recommended.
How serious is the interaction between Edoxaban and Nifedipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed. Remain alert for bleeding, especially in patients with renal impairment or low body weight.
What other medicines interact with Nifedipine?
MediHelp also lists interactions of Nifedipine with, for example, Amifostine, Amlodipine-benazepril, Apalutamide. The full list is on the Nifedipine page.
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