Drug interactions
Edoxaban + Paroxetine
Severity: Moderate
Edoxaban and Paroxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Paroxetine impairs platelet aggregation by depleting platelet serotonin, adding to the anticoagulant effect of edoxaban. This raises the risk of bleeding, especially in the GI tract.
What this interaction means in plain words
Edoxaban and Paroxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Edoxaban belongs to Cardiovascular; Paroxetine belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic effect: SSRI-related platelet dysfunction plus factor Xa inhibition.
What to do
Monitor for bleeding and hemoglobin changes. Consider gastroprotection in patients with other bleeding risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Edoxaban
- Apixaban + Edoxaban Contraindicated
- Defibrotide + Edoxaban Contraindicated
- Edoxaban + Ketorolac Contraindicated
- Abciximab + Edoxaban Major
- Acetylsalicylic acid + Edoxaban Major
- Argatroban + Edoxaban Major
Other interactions of Paroxetine
- Isocarboxazid + Paroxetine Contraindicated
- Methylene blue + Paroxetine Contraindicated
- Paroxetine + Phenelzine Contraindicated
- Paroxetine + Pimozide Contraindicated
- Paroxetine + Procarbazine Contraindicated
- Paroxetine + Selegiline Contraindicated
Frequently asked questions
Can I take Edoxaban with Paroxetine?
MediHelp rates the interaction as moderate. Edoxaban and Paroxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Paroxetine impairs platelet aggregation by depleting platelet serotonin, adding to the anticoagulant effect of edoxaban. This raises the risk of bleeding, especially in the GI tract.
How serious is the interaction between Edoxaban and Paroxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and hemoglobin changes. Consider gastroprotection in patients with other bleeding risk factors.
What other medicines interact with Edoxaban?
MediHelp also lists interactions of Edoxaban with, for example, Apixaban, Defibrotide, Ketorolac. The full list is on the Edoxaban page.
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