Drug interactions
Edoxaban + Quinine
Severity: Moderate
Edoxaban and Quinine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinine inhibits P-glycoprotein, which can increase edoxaban absorption and exposure. This may raise the risk of bleeding.
What this interaction means in plain words
Edoxaban and Quinine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Edoxaban belongs to Cardiovascular; Quinine belongs to Anti Parasitic.
Why it happens
Inhibition of P-glycoprotein efflux increases edoxaban bioavailability.
What to do
Monitor for bleeding and consider edoxaban dose reduction per labeling for venous thromboembolism treatment. Reassess renal function and avoid other interacting drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quinine
- Arsenic trioxide + Quinine Contraindicated
- Dofetilide + Quinine Contraindicated
- Dronedarone + Quinine Contraindicated
- Ibutilide + Quinine Contraindicated
- Mefloquine + Quinine Contraindicated
- Nilotinib + Quinine Contraindicated
Other interactions of Edoxaban
- Apixaban + Edoxaban Contraindicated
- Defibrotide + Edoxaban Contraindicated
- Edoxaban + Ketorolac Contraindicated
- Abciximab + Edoxaban Major
- Acetylsalicylic acid + Edoxaban Major
- Argatroban + Edoxaban Major
Frequently asked questions
Can I take Edoxaban with Quinine?
MediHelp rates the interaction as moderate. Edoxaban and Quinine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quinine inhibits P-glycoprotein, which can increase edoxaban absorption and exposure. This may raise the risk of bleeding.
How serious is the interaction between Edoxaban and Quinine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and consider edoxaban dose reduction per labeling for venous thromboembolism treatment. Reassess renal function and avoid other interacting drugs.
What other medicines interact with Quinine?
MediHelp also lists interactions of Quinine with, for example, Arsenic trioxide, Dofetilide, Dronedarone. The full list is on the Quinine page.
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