Drug interactions
Edoxaban + Sotorasib
Severity: Moderate
Edoxaban and Sotorasib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sotorasib is a P-gp inhibitor and is more likely to raise than lower edoxaban exposure, which could increase bleeding risk. Clinical data on this pair are limited.
What this interaction means in plain words
Edoxaban and Sotorasib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Edoxaban belongs to Cardiovascular; Sotorasib belongs to Oncology.
Why it happens
Sotorasib inhibits P-glycoprotein, which may reduce edoxaban efflux.
What to do
Monitor for signs of bleeding and renal function. Consider an alternative anticoagulant if bleeding risk is otherwise high.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Edoxaban
- Apixaban + Edoxaban Contraindicated
- Defibrotide + Edoxaban Contraindicated
- Edoxaban + Ketorolac Contraindicated
- Abciximab + Edoxaban Major
- Acetylsalicylic acid + Edoxaban Major
- Argatroban + Edoxaban Major
Other interactions of Sotorasib
- Amobarbital + Sotorasib Major
- Apalutamide + Sotorasib Major
- Carbamazepine + Sotorasib Major
- Colchicine + Sotorasib Major
- Cyclosporin + Sotorasib Major
- Digoxin + Sotorasib Major
Frequently asked questions
Can I take Edoxaban with Sotorasib?
MediHelp rates the interaction as moderate. Edoxaban and Sotorasib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sotorasib is a P-gp inhibitor and is more likely to raise than lower edoxaban exposure, which could increase bleeding risk. Clinical data on this pair are limited.
How serious is the interaction between Edoxaban and Sotorasib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of bleeding and renal function. Consider an alternative anticoagulant if bleeding risk is otherwise high.
What other medicines interact with Edoxaban?
MediHelp also lists interactions of Edoxaban with, for example, Apixaban, Defibrotide, Ketorolac. The full list is on the Edoxaban page.
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