Drug interactions
Edoxaban + Sunitinib
Severity: Moderate
Edoxaban and Sunitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sunitinib may inhibit P-glycoprotein and itself carries bleeding risk, so combination with edoxaban may increase hemorrhage.
What this interaction means in plain words
Edoxaban and Sunitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Edoxaban belongs to Cardiovascular; Sunitinib belongs to Oncology.
Why it happens
Possible P-gp inhibition raising edoxaban exposure, plus additive bleeding tendency from sunitinib.
What to do
Monitor for bleeding and platelet counts; consider an edoxaban dose reduction in patients with additional risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Edoxaban
- Apixaban + Edoxaban Contraindicated
- Defibrotide + Edoxaban Contraindicated
- Edoxaban + Ketorolac Contraindicated
- Abciximab + Edoxaban Major
- Acetylsalicylic acid + Edoxaban Major
- Argatroban + Edoxaban Major
Other interactions of Sunitinib
- Adagrasib + Sunitinib Major
- Amiodarone + Sunitinib Major
- Amisulpride + Sunitinib Major
- Anagrelide + Sunitinib Major
- Apalutamide + Sunitinib Major
- Arsenic trioxide + Sunitinib Major
Frequently asked questions
Can I take Edoxaban with Sunitinib?
MediHelp rates the interaction as moderate. Edoxaban and Sunitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sunitinib may inhibit P-glycoprotein and itself carries bleeding risk, so combination with edoxaban may increase hemorrhage.
How serious is the interaction between Edoxaban and Sunitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and platelet counts; consider an edoxaban dose reduction in patients with additional risk factors.
What other medicines interact with Edoxaban?
MediHelp also lists interactions of Edoxaban with, for example, Apixaban, Defibrotide, Ketorolac. The full list is on the Edoxaban page.
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