Drug interactions
Edoxaban + Tirofiban
Severity: Major
Edoxaban and Tirofiban: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tirofiban is a glycoprotein IIb/IIIa inhibitor, and combined with edoxaban it increases the risk of significant bleeding. Haemorrhage at puncture sites and in the gastrointestinal tract is of most concern.
What this interaction means in plain words
Edoxaban and Tirofiban can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Edoxaban belongs to Cardiovascular; Tirofiban belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic effects of glycoprotein IIb/IIIa blockade and factor Xa inhibition.
What to do
Avoid the combination unless clearly needed, and keep overlap as short as possible. Monitor haemoglobin, platelet count and for signs of bleeding.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Edoxaban
- Apixaban + Edoxaban Contraindicated
- Defibrotide + Edoxaban Contraindicated
- Edoxaban + Ketorolac Contraindicated
- Abciximab + Edoxaban Major
- Acetylsalicylic acid + Edoxaban Major
- Argatroban + Edoxaban Major
Other interactions of Tirofiban
Frequently asked questions
Can I take Edoxaban with Tirofiban?
MediHelp rates the interaction as major. Edoxaban and Tirofiban can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tirofiban is a glycoprotein IIb/IIIa inhibitor, and combined with edoxaban it increases the risk of significant bleeding. Haemorrhage at puncture sites and in the gastrointestinal tract is of most concern.
How serious is the interaction between Edoxaban and Tirofiban?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination unless clearly needed, and keep overlap as short as possible. Monitor haemoglobin, platelet count and for signs of bleeding.
What other medicines interact with Edoxaban?
MediHelp also lists interactions of Edoxaban with, for example, Apixaban, Defibrotide, Ketorolac. The full list is on the Edoxaban page.
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