Drug interactions
Edoxaban + Vandetanib
Severity: Moderate
Edoxaban and Vandetanib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vandetanib inhibits P-glycoprotein and may increase edoxaban exposure, raising bleeding risk. Vandetanib itself carries bleeding and QT concerns in patients.
What this interaction means in plain words
Edoxaban and Vandetanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Edoxaban belongs to Cardiovascular; Vandetanib belongs to Oncology.
Why it happens
Inhibition of P-gp efflux increases edoxaban absorption.
What to do
Monitor for bleeding and renal function. Consider an alternative anticoagulant if the patient has other bleeding risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Edoxaban
- Apixaban + Edoxaban Contraindicated
- Defibrotide + Edoxaban Contraindicated
- Edoxaban + Ketorolac Contraindicated
- Abciximab + Edoxaban Major
- Acetylsalicylic acid + Edoxaban Major
- Argatroban + Edoxaban Major
Other interactions of Vandetanib
- Amiodarone + Vandetanib Contraindicated
- Amisulpride + Vandetanib Contraindicated
- Amitriptyline + Vandetanib Contraindicated
- Anagrelide + Vandetanib Contraindicated
- Asenapine + Vandetanib Contraindicated
- Chloroquine + Vandetanib Contraindicated
Frequently asked questions
Can I take Edoxaban with Vandetanib?
MediHelp rates the interaction as moderate. Edoxaban and Vandetanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vandetanib inhibits P-glycoprotein and may increase edoxaban exposure, raising bleeding risk. Vandetanib itself carries bleeding and QT concerns in patients.
How serious is the interaction between Edoxaban and Vandetanib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and renal function. Consider an alternative anticoagulant if the patient has other bleeding risk factors.
What other medicines interact with Edoxaban?
MediHelp also lists interactions of Edoxaban with, for example, Apixaban, Defibrotide, Ketorolac. The full list is on the Edoxaban page.
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