Drug interactions
Efavirenz + Eliglustat
Severity: Major
Efavirenz and Eliglustat: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Efavirenz markedly lowers eliglustat exposure through CYP3A4 induction, risking loss of efficacy. Both may also prolong the QT interval.
What this interaction means in plain words
Efavirenz and Eliglustat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Efavirenz belongs to Anti Virals; Eliglustat belongs to Miscellaneous.
Why it happens
Efavirenz induces CYP3A4 metabolism of eliglustat, and both have QT-prolonging potential.
What to do
Avoid the combination and consider alternative antiretroviral therapy. If it is unavoidable, monitor clinical response and ECG.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Efavirenz
- Cobimetinib + Efavirenz Contraindicated
- Dienogest / estradiol valerate + Efavirenz Contraindicated
- Dihydroergotamine intranasal + Efavirenz Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Doravirine + Efavirenz Contraindicated
- Efavirenz + Elbasvir / grazoprevir Contraindicated
Other interactions of Eliglustat
- Amiodarone + Eliglustat Contraindicated
- Clarithromycin + Eliglustat Contraindicated
- Dronedarone + Eliglustat Contraindicated
- Eliglustat + Itraconazole Contraindicated
- Eliglustat + Ketoconazole Contraindicated
- Eliglustat + Pimozide Contraindicated
Frequently asked questions
Can I take Efavirenz with Eliglustat?
MediHelp rates the interaction as major. Efavirenz and Eliglustat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Efavirenz markedly lowers eliglustat exposure through CYP3A4 induction, risking loss of efficacy. Both may also prolong the QT interval.
How serious is the interaction between Efavirenz and Eliglustat?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and consider alternative antiretroviral therapy. If it is unavoidable, monitor clinical response and ECG.
What other medicines interact with Efavirenz?
MediHelp also lists interactions of Efavirenz with, for example, Cobimetinib, Dienogest / estradiol valerate, Dihydroergotamine intranasal. The full list is on the Efavirenz page.
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