Drug interactions
Efavirenz + Gemifloxacin
Severity: Moderate
Efavirenz and Gemifloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Efavirenz can prolong the QT interval, particularly at higher exposures, and gemifloxacin adds to this effect. Combined use may increase the risk of arrhythmia in susceptible patients.
What this interaction means in plain words
Efavirenz and Gemifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Efavirenz belongs to Anti Virals; Gemifloxacin belongs to Anti Bacterial.
Why it happens
Additive prolongation of ventricular repolarization.
What to do
Check baseline ECG and electrolytes in patients with cardiac risk factors. Monitor QTc and consider an alternative antibiotic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gemifloxacin
- Arsenic trioxide + Gemifloxacin Contraindicated
- Dofetilide + Gemifloxacin Contraindicated
- Gemifloxacin + Ibutilide Contraindicated
- Gemifloxacin + Pimozide Contraindicated
- Gemifloxacin + Thioridazine Contraindicated
- Gemifloxacin + Vandetanib Contraindicated
Other interactions of Efavirenz
- Cobimetinib + Efavirenz Contraindicated
- Dienogest / estradiol valerate + Efavirenz Contraindicated
- Dihydroergotamine intranasal + Efavirenz Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Doravirine + Efavirenz Contraindicated
- Efavirenz + Elbasvir / grazoprevir Contraindicated
Frequently asked questions
Can I take Efavirenz with Gemifloxacin?
MediHelp rates the interaction as moderate. Efavirenz and Gemifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Efavirenz can prolong the QT interval, particularly at higher exposures, and gemifloxacin adds to this effect. Combined use may increase the risk of arrhythmia in susceptible patients.
How serious is the interaction between Efavirenz and Gemifloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline ECG and electrolytes in patients with cardiac risk factors. Monitor QTc and consider an alternative antibiotic.
What other medicines interact with Gemifloxacin?
MediHelp also lists interactions of Gemifloxacin with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Gemifloxacin page.
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