Drug interactions
Efavirenz + Lurasidone
Severity: Moderate
Efavirenz and Lurasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Efavirenz, a moderate CYP3A4 inducer, can lower lurasidone concentrations and reduce antipsychotic effect. Additive CNS effects are also possible.
What this interaction means in plain words
Efavirenz and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Efavirenz belongs to Anti Virals; Lurasidone belongs to Central Nervous System.
Why it happens
CYP3A4 induction increases lurasidone clearance, with additive CNS depression.
What to do
Monitor psychiatric response and consider increasing the lurasidone dose after sustained efavirenz use. Reduce the dose again if efavirenz is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Efavirenz
- Cobimetinib + Efavirenz Contraindicated
- Dienogest / estradiol valerate + Efavirenz Contraindicated
- Dihydroergotamine intranasal + Efavirenz Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Doravirine + Efavirenz Contraindicated
- Efavirenz + Elbasvir / grazoprevir Contraindicated
Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Frequently asked questions
Can I take Efavirenz with Lurasidone?
MediHelp rates the interaction as moderate. Efavirenz and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Efavirenz, a moderate CYP3A4 inducer, can lower lurasidone concentrations and reduce antipsychotic effect. Additive CNS effects are also possible.
How serious is the interaction between Efavirenz and Lurasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor psychiatric response and consider increasing the lurasidone dose after sustained efavirenz use. Reduce the dose again if efavirenz is stopped.
What other medicines interact with Efavirenz?
MediHelp also lists interactions of Efavirenz with, for example, Cobimetinib, Dienogest / estradiol valerate, Dihydroergotamine intranasal. The full list is on the Efavirenz page.
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