Drug interactions
Efavirenz + Nisoldipine
Severity: Moderate
Efavirenz and Nisoldipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Efavirenz can lower nisoldipine plasma concentrations because nisoldipine is extensively metabolized by CYP3A4. Reduced exposure may lead to loss of blood pressure or angina control.
What this interaction means in plain words
Efavirenz and Nisoldipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Efavirenz belongs to Anti Virals; Nisoldipine belongs to Cardiovascular.
Why it happens
Efavirenz induces intestinal and hepatic CYP3A4, increasing first-pass and systemic clearance of nisoldipine.
What to do
Monitor blood pressure and anginal symptoms and titrate nisoldipine upward as needed. Consider an alternative antihypertensive not dependent on CYP3A4 if control is inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Efavirenz
- Cobimetinib + Efavirenz Contraindicated
- Dienogest / estradiol valerate + Efavirenz Contraindicated
- Dihydroergotamine intranasal + Efavirenz Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Doravirine + Efavirenz Contraindicated
- Efavirenz + Elbasvir / grazoprevir Contraindicated
Other interactions of Nisoldipine
- Itraconazole + Nisoldipine Contraindicated
- Ketoconazole + Nisoldipine Contraindicated
- Apalutamide + Nisoldipine Major
- Carbamazepine + Nisoldipine Major
- Chloramphenicol + Nisoldipine Major
- Clarithromycin + Nisoldipine Major
Frequently asked questions
Can I take Efavirenz with Nisoldipine?
MediHelp rates the interaction as moderate. Efavirenz and Nisoldipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Efavirenz can lower nisoldipine plasma concentrations because nisoldipine is extensively metabolized by CYP3A4. Reduced exposure may lead to loss of blood pressure or angina control.
How serious is the interaction between Efavirenz and Nisoldipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and anginal symptoms and titrate nisoldipine upward as needed. Consider an alternative antihypertensive not dependent on CYP3A4 if control is inadequate.
What other medicines interact with Efavirenz?
MediHelp also lists interactions of Efavirenz with, for example, Cobimetinib, Dienogest / estradiol valerate, Dihydroergotamine intranasal. The full list is on the Efavirenz page.
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