Drug interactions
Efavirenz + Oxaliplatin
Severity: Moderate
Efavirenz and Oxaliplatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have been linked to QT prolongation, so the combination may increase arrhythmia risk, especially with electrolyte loss from chemotherapy such as vomiting or diarrhea.
What this interaction means in plain words
Efavirenz and Oxaliplatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Efavirenz belongs to Anti Virals; Oxaliplatin belongs to Oncology.
Why it happens
Additive QT prolongation.
What to do
Check a baseline ECG and monitor potassium and magnesium during chemotherapy cycles. Replace electrolytes promptly and reassess the antiretroviral if the QTc rises.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Efavirenz
- Cobimetinib + Efavirenz Contraindicated
- Dienogest / estradiol valerate + Efavirenz Contraindicated
- Dihydroergotamine intranasal + Efavirenz Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Doravirine + Efavirenz Contraindicated
- Efavirenz + Elbasvir / grazoprevir Contraindicated
Other interactions of Oxaliplatin
- Adenovirus types 4 and 7 live + Oxaliplatin Contraindicated
- Bcg vaccine live + Oxaliplatin Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine live + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine + Oxaliplatin Contraindicated
- Measles mumps rubella and varicella vaccine live + Oxaliplatin Contraindicated
Frequently asked questions
Can I take Efavirenz with Oxaliplatin?
MediHelp rates the interaction as moderate. Efavirenz and Oxaliplatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have been linked to QT prolongation, so the combination may increase arrhythmia risk, especially with electrolyte loss from chemotherapy such as vomiting or diarrhea.
How serious is the interaction between Efavirenz and Oxaliplatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG and monitor potassium and magnesium during chemotherapy cycles. Replace electrolytes promptly and reassess the antiretroviral if the QTc rises.
What other medicines interact with Efavirenz?
MediHelp also lists interactions of Efavirenz with, for example, Cobimetinib, Dienogest / estradiol valerate, Dihydroergotamine intranasal. The full list is on the Efavirenz page.
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