Drug interactions
Efavirenz + Pomalidomide
Severity: Minor
Efavirenz and Pomalidomide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pomalidomide is partly metabolized by CYP3A4, so efavirenz may modestly lower its exposure. The clinical consequence is likely small because CYP1A2 is the main pathway.
What this interaction means in plain words
Efavirenz and Pomalidomide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Efavirenz belongs to Anti Virals; Pomalidomide belongs to Miscellaneous.
Why it happens
Weak CYP3A4 induction by efavirenz may increase pomalidomide clearance.
What to do
No dose adjustment is generally needed; monitor disease response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Efavirenz
- Cobimetinib + Efavirenz Contraindicated
- Dienogest / estradiol valerate + Efavirenz Contraindicated
- Dihydroergotamine intranasal + Efavirenz Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Doravirine + Efavirenz Contraindicated
- Efavirenz + Elbasvir / grazoprevir Contraindicated
Other interactions of Pomalidomide
- Deferiprone + Pomalidomide Major
- Ethinyl estradiol-drospirenone + Pomalidomide Major
- Fluvoxamine + Pomalidomide Major
- Apalutamide + Pomalidomide Moderate
- Brivaracetam + Pomalidomide Moderate
- Carbamazepine + Pomalidomide Moderate
Frequently asked questions
Can I take Efavirenz with Pomalidomide?
MediHelp rates the interaction as minor. Efavirenz and Pomalidomide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pomalidomide is partly metabolized by CYP3A4, so efavirenz may modestly lower its exposure. The clinical consequence is likely small because CYP1A2 is the main pathway.
How serious is the interaction between Efavirenz and Pomalidomide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is generally needed; monitor disease response.
What other medicines interact with Efavirenz?
MediHelp also lists interactions of Efavirenz with, for example, Cobimetinib, Dienogest / estradiol valerate, Dihydroergotamine intranasal. The full list is on the Efavirenz page.
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