Drug interactions
Efavirenz + Rimegepant
Severity: Moderate
Efavirenz and Rimegepant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Efavirenz is a moderate-to-strong CYP3A4 inducer and may reduce rimegepant concentrations. This could lessen its effectiveness for migraine.
What this interaction means in plain words
Efavirenz and Rimegepant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Efavirenz belongs to Anti Virals; Rimegepant belongs to Central Nervous System.
Why it happens
Efavirenz induces CYP3A4, accelerating rimegepant metabolism.
What to do
Avoid repeating rimegepant doses within 48 hours if a dose is taken with a moderate CYP3A4 inducer, and monitor migraine control. Consider another acute migraine therapy if efficacy falls.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Efavirenz
- Cobimetinib + Efavirenz Contraindicated
- Dienogest / estradiol valerate + Efavirenz Contraindicated
- Dihydroergotamine intranasal + Efavirenz Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Doravirine + Efavirenz Contraindicated
- Efavirenz + Elbasvir / grazoprevir Contraindicated
Other interactions of Rimegepant
Frequently asked questions
Can I take Efavirenz with Rimegepant?
MediHelp rates the interaction as moderate. Efavirenz and Rimegepant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Efavirenz is a moderate-to-strong CYP3A4 inducer and may reduce rimegepant concentrations. This could lessen its effectiveness for migraine.
How serious is the interaction between Efavirenz and Rimegepant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid repeating rimegepant doses within 48 hours if a dose is taken with a moderate CYP3A4 inducer, and monitor migraine control. Consider another acute migraine therapy if efficacy falls.
What other medicines interact with Efavirenz?
MediHelp also lists interactions of Efavirenz with, for example, Cobimetinib, Dienogest / estradiol valerate, Dihydroergotamine intranasal. The full list is on the Efavirenz page.
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